Fatigue CFS/ME

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A pervasive and long-term feeling of exhaustion without there being a cause, is also a symptom of PDS. Fatigue can be explained because the tonic fibre component of muscles throughout the body remains contracted for long periods of time, without the normal periods of relaxation - note that the normal physiology of the tonic fibre component of muscles is such that there is a constant tonic oscillation of contraction and relaxation.